DermaTechRx Research Center

Griseofulvin Tinea Capitis

Tinea capitis, or ringworm of the scalp, is the most common dermatophyte infection among children.  This is a problem worldwide but approximately 3 to 8 percent of American children are affected, and up to one third of in-house contacts are asymptomatic carriers, meaning they show no outward signs of the infection. Tinea infections are usually spread by humans but may also be passed to humans from animals. Adolescent and adult infections are uncommon.

The three primary dermatophytes most commonly seen are Trichophyton tonsurans, Microsporum audouinii and Microsporum canis. Anti-fungal medications, taken by mouth, are used to treat the infection. There are several different options that are often used to treat this condition.  Griseofulvin has long been the standard therapy for tinea capitis.  It is currently the only antifungal agent labeled by the U.S. Food and Drug Administration for this condition. Griseofulvin is an antibiotic derived from a species of Penicillium.

Griseofulvin acts systemically to inhibit the growth of Trichophyton, Microsporum, and Epidermophyton genera of fungi. With the use of an anti-fungal like griseofulvin Tinea Capitis can be treated effectively.  Fungistatic amounts are deposited in the keratin, which is gradually exfoliated and replaced by non-infected tissue.  Griseofulvin absorption from the gastrointestinal tract varies considerably from one individual to the next. This is mainly because of insolubility of the drug in the upper G.I. tract. The peak serum level found in fasting adults given 0.5 gm occurs at about four hours and ranges between 0.5 and 2.0 mcg/mL.

As previously mentioned some individuals do not absorb at the same rate as others and tend to attain lower blood levels at all times. This may explain why some patients respond better to this type of treatment than others. Better blood levels can probably be attained in most patients if Griseofulvin is taken after ingesting a meal with a high fat content.

Some of the symptoms of tinea capitis or scalp ringworm to watch for are bald patched areas, where hair that has broken off from the scalp, itching of the scalp, pus-filled lesions or sores on the scalp, round, scaly lesions on the scalp that may be inflamed, and small black dots on the scalp. Tinea capitis may be extremely persistent, and it may return after treatment. It has been found that in many cases it goes away on its own as a person reaches puberty.  Good general hygiene is a key factor to prevent and treat tinea infections.